Ketogenic diet - Wikipedia, the free encyclopedia

Ketogenic diet - Wikipedia, the free encyclopedia: "Diet
In 1921, Rollin Woodyatt reviewed the research on diet and diabetes. He reported that three water-soluble compounds, β-hydroxybutyrate, acetoacetate and acetone (known as ketone bodies) were produced by the liver in otherwise healthy people when they were starved or if they consumed a diet that is too low in carbohydrate and too high in fat. Russel Wilder, at the Mayo Clinic, built on this research and coined the term ketogenic diet to describe a diet that produced a high level of ketones in the blood (ketonemia) through an excess of fat and lack of carbohydrate. Wilder hoped to obtain the benefits of fasting in a dietary therapy that could be maintained indefinitely. His trial, in 1921, on a few epilepsy patients was the first use of the ketogenic diet as a treatment for epilepsy.[5]
Wilder's colleague, paediatrician Mynie Peterman, later formulated the 'classic' diet, with a ratio of one gram of protein per kg of body weight in children, 10–15 g of carbohydrate per day, and the remainder of calories from fat. Peterman's work, in the 1920s, established the techniques for induction and maintenance of the diet, and documented both positive and negative side effects. During this period, the Massachusetts General Hospital, under Fritz Talbot, established their ketogenic diet programme, which was very similar to the current one at Johns Hopkins Hospital. Talbot proposed that the ideal therapeutic ratio of fat to combined protein and carbohydrate was 4:1. He was the first to monitor the level of excess ketone production (ketosis) by measuring the amount excreted in the urine (ketonuria).[5]"